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REGULATION OF FIH EXPRESSION IN RENAL CANCER

2009-09-13 01:41 from: cf auther: cf read:
REGULATION OF FIH EXPRESSION IN RENAL CANCER: Hydroxylation at an asparagine residue at the C-terminal activation domain of hypoxia inducible factor-1/2 a s (HIF a ) is essential for its inactivation under normoxic condition. To date, the m

REGULATION OF FIH EXPRESSION IN RENAL CANCER:

Hydroxylation at an asparagine residue at the C-terminal activation domain of hypoxia inducible factor-1/2 a s (HIF a ) is essential for its inactivation under normoxic condition. To date, the mechanism by which HIF a avoids the inhibitory effect of asparagine hydroxylase in renal cell carcinoma (RCC) in normoxia is undefined. We have shown herein that protein kinase C zeta (PKC z ) has an important role in HIF a activation in RCC.

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